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Author Topic: Progress in research of the Covid-19 ARV around the world  (Read 183 times)


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Progress in research of the Covid-19 ARV around the world

Currently, the number of people infected with Covid-19 There is a trend increasing steadily. And there is no direct vaccine to prevent or prevent the Covid-19 virus. Currently, in many countries Including Thailand, using antiretroviral drugs such as Risk aversion, influenza, SARS or Ebola as a drug used to treat Covid-19. And use as a base for vaccine development

But even then, there has been cooperation from the public and private sectors and famous universities. Jointly research the antiviral and vaccine vaccines Covid-19 Which has been researched since the beginning of the outbreak In which each country has made progress But according to the BBC's report, although scientists are able to produce a vaccine to protect against Covid-19 Catch up before Christmas this year But the process of public production in order to distribute, use, takes quite a bit. Let's take a look at the progress of each country in the vaccination of the Covid-19 vaccine. Where then

The Government Pharmaceutical Organization has already imported 40,000 faviravir pills, which can support approximately 800 patients. Thai people are ready to be producers if the raw materials are sufficient.

On 28 February 2020, Deputy Prime Minister and Minister of Health, Anutin Charnwirakul confirmed that the drug is resistant to COV-19. That the Chinese government has donated to Thailand Has arrived in Thailand successfully, and also the purchase of anti-Chinese drugs.

On March 6, 2020, Dr. Withun Danwibun, director of the Pharmaceutical Organization, revealed that The Government Pharmaceutical Organization has collaborated with the Department of Disease Control. To reserve 40,000 tablets of such drugs, able to be used by 800 patients, and confirm that Thailand is efficient and the area to produce such drugs in accordance with GMP standards.

In addition, the Government Pharmaceutical Organization Also accelerated the production of antiretroviral drugs Lopinavir / Ritonavir (Lopinavir / ritonavir) and influenza antiretroviral drugs Oseltamivir Which is a drug that Rajavithi Hospital used to treat Covid-19 patients effectively, including the production of chloroquine (Chloroquine), which is also used to treat malaria

Regarding the research on vaccine against Covid-19 in Thailand, Dr. Sukhum Kanchanapimai, Permanent Secretary of the Ministry of Public Health (Ministry of Public Health) said that the cooperation was signed to develop the vaccine-Covid-19. Together with representatives from 11 departments consisting of Mahidol University Chulalongkorn University National Research Office Bionet-Asia Company Limited Office of the Permanent Secretary Ministry of Public Health Department of Medical Services Department of Disease Control Department of Medical Sciences Food and Drug Administration Government Pharmaceutical Organization And the National Vaccine Institute To continue developing this vaccine

In addition, in the development of the vaccine The Department of Medical Sciences was able to cultivate the Covid 19 virus as the first country in the world. If China is not counted and this successful culture will be able to produce vaccines against the virus in the future

The Tianan University in China Revealed that it was successful in the production of oral antiviral drugs in the testing process.

On February 25, the Global Times newspaper reported that Tianjin University In China, it has been successful in developing an oral vaccine against the Covid-19 virus. Huang Jin Hai, a university professor, tested this vaccine himself. And without any side effects And the University of Tianjin is looking for a partner to push in the clinical process and take it to a wider scale, stating that it is safe for patients and can produce quickly in large quantities.

At the same time, it is predicted that Although the development process is complete, the testing process may take approximately 18 months or longer.

Institutional scientists in the research institute MIGAL in Israel expects to be able to produce a vaccine against the Covid-19 virus within 8-10 weeks on March 2. Pharmaceutical-Technology Reported that institutional scientists in the research institute MIGAL in Israel is expected to start producing the vaccine Covid-19 in the next 8-10 weeks, the discovery of the drug is a by-product of research and development of the vaccine IBV (Infectious bronchitis virus), a vaccine used to treat the disease. Bronchitis that contacts in  Yield curve option-pricing modelsen At the moment, the MIGAL Institute has genetically modified it to be Covid-19. And is conducting safety certification in order to be used in human body testing for anti-cowid-19 That is pandemic around the world

However, Professor Christine McCarthy, a pediatrician specializing in infectious diseases and vaccines at the University of Sydney, spoke of this development. That is a very interesting development, but an 8-10 week time frame for trials and distribution for people who need vaccines That's too early
United States and China

Inovio Pharmaceuticals Inc and Beijing Advaccine Biotechnology. Join hands to develop the vaccine INO-4800 by Inovio Pharmaceuticals Inc, a pharmaceutical company based in the state of Pleasantia. United States of America Announced an urgent schedule for the development of the INO-4800 vaccine for the Covid-19 virus.

Inovio announced in late January that it is developing an INO-4800 vaccine in partnership with Beijing Advaccine Biotechnology. At that time, Beijing Advaccine said it had begun animal testing and was preparing clinical products for Phase I trials planned in China. And also increasing clinical development efforts in the United States. Inovio is one of the companies that are developing treatment or vaccines for Covid-19, causing Inovio shares to jump 18.68% to $ 5.21 at the time of the announcement of the partnership.

With a schedule announcement by Dr. Joseph Kim, chief executive of Inovio Company, on Monday That the company will have human trials this March And will summarize the results of the experiment in humans and publish in the autumn 2020, which, if planned Will be able to produce 1 million doses of INO-4800 by the end of this year. All of which are still the short-term planning

In addition, Moderna Therapeutics from the United States delivered the Vaccine-19 vaccine to the Institute of Allergy and Infectious Diseases (NIAID) for human testing in April.

The Civid-19 vaccine from Moderna Therapeutics is being developed at the Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health (NIH) in Bethesda. Maryland The NIH scientists are testing an antiviral drug called 'Remdesivie' developed for Ebola-infected people, which will now be used in the treatment of Covid-19.

In addition, the United States Prepare to test Remdesivir by submitting it to more than 50 medical centers around the world for antiretroviral testing. The World Health Organization said that remdesivir is an effective antiviral drug. After used to test 2 patients in Wuhan and as a drug to treat patients Covid-19 The first in the United States as well. After treatment The patient has improved symptoms.

In the United States, drug use is still Kaletra, which is a combination of two drugs that are used against Risk aversion, which have already been tested in patients infected with China.
Canada and Austria

British Columbia University in Canada joins forces with Apeiron Biologics in Austria to develop the vaccine APN01.

Researchers from the University of British Columbia in Canada, together with the Austrian company Apeiron Biologics, have developed the APN01 vaccine for the treatment of patients from the Covid-19 disease in China by Dr. Joseph Penninger, director of the UBC Life Sciences Institute. Find APN01 together with researchers from the University of Toronto and Peking Medical Union.

Dr. Joseph said that the drug began to develop from the ACE2-based SARS virus, so the method for treating Covid-19 infected people was using ACE2 to create a vaccine for treatment. Predicted that the drug APN01 could reduce the virus And preventing infections that will damage the lungs

Now talking about Yaphavipiravir Quite a lot Which has been tried in both China and the United States as well 'Favipiravir', also known as T-705 or Avigan, is an antiviral drug developed by Toyama Chemical Company. Japan

Pharmaviravir has been manufactured by Toyama Chemical Company. Japan Which has been developed and tested in humans in the past February Pharmaviravir has a inhibitory effect. RNA-dependent RNA polymerase of influenza virus Causing the virus to not be able to multiply And spread throughout the body. On February 16, the Chinese Medical Product Administration Office has certified that This drug can be opposed to Rusovic-19, and today the company Zhejiang Hai Xun Chinese medical giant Received government approval for drug production and distribution


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